This composition contains amoxycillin and clavulanic acid which are used to treat bacterial Infections. Amoxycillin has longer duration of action. It also causes upregulation of autolytic enzymes and has wide therapeutic range. Amoxycillin along with clavulanic acid to overcome resistance.
Bacterial sinusitis
Community acquired pneumonia
Skin infections
Lower respiratory tract infections
Amoxycillin inhibits the penicillin binding proteins, PBP is responsible for transpeptidase reactions and also for crosslinking between D-alanine and D-aspartic acid.
Clavulanic acid contains beta-lactam ring in its structure and inhibit it and prevent other antibiotics from its action.
Amoxycillin-
It is absorbed orally
It is 17% bound to plasma proteins
It undergoes deamination and oxidation
It is excreted via urine
Clavulanic acid-
It is well absorbed by GIT
It is metabolized by the liver
It is excreted via urine
Nausea
Vomiting
Diarrhea
Stomach pain
Abdominal pain
Gas
Probenecid
Warfarin
Allopurinol
Coumadin
| Amoxycillin Trihydrate IP | 200 mg |
| Potassium Clavulanate | 28.5 mg |